|
|
What is Anticoagulation & Thrombosis?
Anticoagulation is the prevention of coagulation, or blood clotting.
Only coagulation permits secure closure of the wound, a process only finally completed when the wound has healed.
Nature makes sure that coagulation takes place quickly so that as little as possible of the valuable blood is lost either externally, e.g. after a cut, or internally if the blood enters the tissues, i.e. internal bleeding occurs.
The body therefore has a dozen or so coagulation factors designated by Roman numerals in the order of their discovery (e.g. factor II, VII). These coagulation factors are blood proteins and are produced in the liver.
Under the influence of vitamin K, some of them, namely factors II, VII, IX and X, are altered in such a way that, in the event of an injury, they are able to bind to the platelets already adhering to the wound surface and to other coagulation factors. In order for this binding to take place, calcium is also required as a bridge, i.e. without free calcium coagulation is not possible.
|
 |
|
 |
Management of Myocardial Infarction
Provided by: The Ohio State University Medical Center
Description
According to National Institutes of Health, most heart attacks are caused by a blood clot that blocks one of the coronary arteries. The coronary arteries bring blood and oxygen to the heart. If the blood flow is blocked, the heart starves for oxygen and heart cells die.
Objectives
Upon completion of this educational acitivity the p... |
 |
Thrombosis in Children
Provided by: CMElectures
Leslie Raffini, MD, is an assistant professor of pediatrics in the Division of hematology at Children's Hospital of Philadelphia. She is currently completing a National Hemophilia-sponsored fellowship in clinical hemostasis and thrombosis. She has completed a two-year National Hemophilia Foundation sponsored fellowship in clinical hemostasis. Here,... |
 |
A Novel Thromboelastographic Score to Identify Overt Disseminated Intravascular Coagulation Resulting in a Hypocoagulable State
Provided by: American Society for Clinical Pathology
Upon completion of this activity, you will be able to:
* describe the underlying principle of thromboelastography as a test of hemostasis as well as some of its major limitations.
* list the individual components of the International Society on Thrombosis and Haemostasis scoring algorithm for overt disseminated intravascular coagulation.
*... |
|
Inherited Bleeding Disorders
Provided by: CMElectures
Dr. Raffini, M.D., is assistant professor of pediatrics -University of Pennsylvania School of Medicine, Philadelphia, PA and attending physician in the division of hematology -Children's Hospital of Philadelphia, Philadelphia, PA. She has completed a two-year National Hemophilia Foundation sponsored fellowship in clinical hemostasis. Here, she disc... |
 |
Evidence Based Treatment of Heart Failure, Anticoagulation, and Pain Management
Provided by: University Learning Systems
Session 1 – Wednesday, August 8, 2012 - An Evidence-Based Heart Failure Review
Session 2 – Thursday, August 9, 2012 - A Comprehensive, Evidence-Based Review of Anticoagulation
Session 3 – Friday, August 10, 2012 - A Comprehensive, Evidenced-Based Review of Treating Pain and Suffering
... |
 |
Managing the Risks of Anticoagulant Therapy
Provided by: Medical Interactive Community
Primary care physicians manage many of the patients on long term anticoagulant therapy. They perform a difficult balancing act on a daily basis, weighing each patient’s risk of thromboembolism versus hemorrhage. The preponderance of current medical literature identifies under-utilization of anticoagulants as a major problem, and cites the burden ... |
|
Platelet Count and Prothrombin Time Help Distinguish Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome From Disseminated Intravascular Coagulation in Adults
Provided by: American Society for Clinical Pathology
Upon completion of this activity, you will be able to:
* describe how the diagnosis of thrombotic thrombocytopenic purpura (TTP) is complicated by its similarities with other conditions such as disseminated intravascular coagulation.
* describe the current understanding of the pathophysiology of TTP.
* discuss the standard therapy for TTP... |
 |
Venous Thrombosis
Provided by: Harvard Medical School
The most common presentations of venous thromboembolism (VTE) are deep vein thrombosis (DVT) of the lower extremity and pulmonary embolism. A risk factor for VTE, either hereditary or acquired, can now be identified in approximately 80 percent of patients. Furthermore, there is often more than one factor at play in a given patient. As an example, 5... |
|
JAK2 Mutations Across a Spectrum of Venous Thrombosis Cases
Provided by: American Society for Clinical Pathology
Upon completion of this activity, you will be able to:
* list the types of thrombi most commonly associated with JAK2 mutations.
* outline the best test methods to detect JAK2 mutations.
* define the risk for and types of myelodysplastic syndromes that may be associated with JAK2 mutations.
... |
 |
Surveying the Landscape of Antiplatelet Therapy: Optimizing Outcomes in Atherothrombotic Disease
Provided by: Voxmedia International
Limitations of clopidogrel therapy for acute coronary syndromes (ACS) have led to the conduct and completion of clinical outcome trials investigating different approaches to reduce ischemic risk. These different approaches include alternative dosing strategies with clopidogrel, as well as more potent oral antiplatelet agents. Clinical trials of the... |
 |
Update on Chronic ITP (Immune Thrombocytopenic Purpura)
Provided by: University of California, Davis, Health System
Forms
CME Credit Application and Disclosure
Accreditation
The UC Davis Health System is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. This CME activity was planned in accordance with the ACCME essentials for enduring materials. Length of time has been ... |
|
Anemia
Provided by: The Ohio State University Medical Center
Upon completion of this educational activity,the participant will be able to: 1.) Recognize how to classify anemias. 2.) Review the use of the CBC in the initial evaluation of anemia and subsequent appropriate lab tests.... |
 |
Focus On: Reversal of Anticoagulation
Provided by: American College of Emergency Physicians
After reading this article, the physician should be able to:
* Understand the indications for reversal of warfarin.
* Identify the side effects of protamine in heparin reversal.
* Recognize the advantages and disadvantages of fresh frozen plasma (FFP) vs. prothrombin complex concentrates (PCC) in the treatment of warfarin reversal.... |
|
Factor V Leiden and Factor V Deficiency: A Tale of Two Disorders. LQCL1008
Provided by: American Society for Clinical Pathology
Upon completion of this activity, you will be able to:
* discuss the difference between the factor V Leiden and factor V assay tests.
* identify the relationships factor V has in the coagulation cascade and explain how factor V Leiden may lead to hypercoagulability.
* discuss the demographics of factor V Leiden.
* compare the clinical p... |
 |
Detecting, Managing, and Preventing Pulmonary Embolism
Provided by: ANA Continuing Online Education
PULMONARY EMBOLISM (PE) occurs when a pulmonary artery becomes blocked-usually by a blood clot that has broken free from its site of origin and embolized or migrated to the lungs. If misdiagnosed, unrecognized, or untreated, PE can cause death quickly-within just an hour. It's fatal in up to 26% of cases.
**Objectives:**
* Describe the pathoph... |
|
Procoagulant Activity in Trauma Patients
Provided by: American Society for Clinical Pathology
Upon completion of this activity, you will be able to:
* describe possible causes and prevention of interference in clot-based activity assays.
* discuss setting and clinical laboratory findings in patients with acute coagulopathy of trauma.
* describe the major form of circulating coagulation activator (procoagulant) in plasma from trauma ... |
|
|
|
Virtual Exhibits / Booths
