Can you answer the following questions about
Trizivir®?
What is the generic name? Any abbreviations?
What "class" antiretroviral is it and how does it work?
With food, without food or food doesn't matter?
Any side effects?
Any hypersensitivity issues?
Any possible drug interactions?
What is a typical dose?
Any other significant counseling points?
Trizivir ® (abacavir/lamivudine/zidovudine)
is a combination of three nucleoside reverse transcriptase inhibitors
(NRTI's) that all inhibit viral
replication.
Retrovir® (Zidovudine) +
Epivir® (Lamivudine) +
Ziagen® (Abacavir, ABC)
Trizivir ®
(abacavir/lamivudine/zidovudine) is dosed 1 tablet
bid.
Trizivir ® (abacavir/lamivudine/zidovudine)
can be taken
with or without food.
Counsel patients on 5% risk of
hypersensitivity reaction associated with
abacavir use. Reaction most often consists
of at least
two of the following:
fever, rash, nausea, vomiting, diarrhea, fatigue, and respiratory symptoms.
Patients experiencing a hypersensitivity reaction should stop antiretroviral
therapy, contact provider, and NEVER receive abacavir
again.
Lactic acidosis with hepatic steatosis is a rare but potentially fatal
toxicity associated with the use of NRTIs.
As with all antiretrovirals, adherence is
crucial. Non-adherence is a
frequent cause of drug failure and viral resistance.
