Pharmacy500 Marketplace

Controlled Substance Ordering, Reporting, CSOS Software

Leading Providers in Controlled Substance Ordering Management, Controlled Drugs Ordering, DEA Form 222 Ordering, DEA Form 222 Software, Controlled Substance Management...

Aisle OVERVIEW

Controlled Substance Reporting Software is specialized software designed to help pharmacies manage, track, and report the handling of controlled substances in compliance with federal and state regulations. It facilitates the monitoring of prescribing and dispensing activities, ensuring accountability and preventing the misuse or diversion of these substances. This software is critical for ensuring compliance with controlled substance regulations, maintaining accurate records, and protecting public health by reducing the risk of substance misuse and diversion. It supports pharmacies in adhering to legal standards while optimizing workflow efficiency.

Company Profiles

Pharmacy500

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The Pharmacy500 is awarded to 500 pharmacy supply chain businesses and associations that significantly impacted dispensing pharmacies in the U.S. over the past year.

Pharmacy500 Benefits

The following are complimentary benefits extended to Pharmacy500 companies and associations (coming this spring!)

  1. Company listings in the Platinum Pages Buyer’s Guide, 20Ways publications, and RXinsider website
  2. Company inclusion in the 20Ways themed Buyer’s Guide
  3. Unlimited job postings in the Pharmacy500 Career Center *Unlimited through 2025
  4. Tradeshow promotional resources including Pharmacy500 floor stickers and lanyards
  5. Two posts (annually) in RXinsider’s Pharmacy Market BUZZ news feed

Who are the Pharmacy500 and what are the selection criteria?

The Pharmacy500 includes:

  1. Companies within the Pharmacy Supply Chain
  2. National Pharmacy Trade Associations

The Pharmacy500 Selection Committee applies the following criteria to determine the list of 500:

  • Offers and actively markets at least one product or service to dispensing pharmacies
  • Dispensing pharmacies comprise at least 25% of their customer base
  • Has an estimated annual revenue exceeding $500,000
  • Has five or more full-time employees, and has been in business for more than two years
  • Has a national presence
  • Exhibited at one of the following national conferences in the previous year: APhA; ASCP Annual Meeting & Exhibition; Asembia’s Summit; ASHP Midyear Clinical Meetings & Exhibition; Cardinal Health RBC; McKesson ideaShare; NACDS Total Store Expo; NASP Annual Meeting & Expo; NCPA Annual Convention and Expo; Pharmacy Futures (ASHP Summer); ThoughtSpot.

The following supply chain segments are critical to pharmacy operations and patient care, but are excluded from the Pharmacy500 simply due to volume:

  • Manufacturers and Merchandisers of Pharmaceuticals
  • Manufacturers and Merchandisers of Devices and OTC Products
  • Colleges of Pharmacy
  • State Associations
  • Government Agencies and State Boards of Pharmacy
  • Pharmacy Fraternities & Sororities
  • Dispensing Pharmacies, Health Systems, Chains, Payors, and PBMs

C2 Keep

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Join Over 2,000 Pharmacists and Staff Who Trust C2 Keep to Bring Peace of Mind 

C2 Keep is a cloud-based, fully integrated controlled substance reporting and compliance solution designed specifically for pharmacies. Founded by former pharmacy director Roland Achenjang after experiencing an embarrassing audit, C2 Keep was built to eliminate the same compliance challenges he and countless others have faced. 

By automating manual tasks, delivering real-time insights, enhancing security, and simplifying reporting, C2 Keep empowers pharmacies to stay compliant and focus on what matters most: ensuring patients receive the right medication at the right time. 

Why Pharmacies Choose C2 Keep 

  • Seamless Integration: C2 Keep is the only controlled substance compliance tool that integrates directly with your pharmacy management system and wholesalers. This provides a unified solution that removes data silos and improves operational efficiency. 
  • Transformative Time Savings: Replace cumbersome manual logbooks and save up to 25 hours per month or $15,000 annually in labor costs. This allows your team to focus more time on patient care and other high-value tasks that support your business. 
  • Real-Time Inventory Insights: C2 Keep’s true perpetual inventory tracking provides instant visibility into controlled substance activity. You and your team can easily maintain accurate records, make informed decisions, and strengthen operational performance. 
  • Enhanced Accountability & Security: Built-in safeguards increase staff accountability and make diversion more difficult. The system also enables quick identification and resolution of discrepancies, which helps create a safer environment for both staff and patients. 
  • Streamlined Compliance Reporting: Generate federal and state-mandated reports in seconds and prepare for DEA or board of pharmacy audits with confidence. C2 Keep simplifies compliance, saving time and reducing stress.
  • Effortless Document Management: Store and retrieve DEA 222 / CSOS documents and other order files in just a few clicks. C2 Keep keeps everything organized and secure, so your pharmacy is always audit-ready. 

Ready to Simplify Compliance? 

Whether you’re a small independent pharmacy or part of a larger chain, C2 Keep scales to meet your unique needs, providing a flexible compliance solution that grows with your business. Visit c2keep.com and schedule a demo to learn more!

Product Highlight SHOWCASE

Subject Matter Expert & Thought Leader PROFILES

Dr. Mark Garofoli is a Clinical Assistant Professor and Director of Experiential Learning for the West Virginia University (WVU) School of Pharmacy, along with being a Clinical Pain Management Pharmacist at the WVU Medicine Center for Integrative Pain Management. Dr. Garofoli received his PharmD at the University of Pittsburgh School of Pharmacy in 2004 and his MBA from Strayer University in 2008. He is board-certified in Geriatric Care (BGCP) along with being a certified pain educator (CPE). Dr. Garofoli began his career with CVS Health in community pharmacy and field management, then transitioned to being a Humana Healthcare MTM clinical pharmacist, which lead him to developing and coordinating the WVU Opioid-Centered MTM program and the Safe & Effective Management of Pain Program and guidelines (www.sempguidelines.org). Mark is a pain management consultant as a CDC grant reviewer, an expert witness, has authored many professional articles and conducted numerous interviews.

Resources & Awareness

The 2026 Pharmacy500 Companies Market Teardown report provides a concise snapshot of the 2026 companies, highlighting new additions, examining regional distributions, practice settings, supply chain categories, and key conferences attended.

RXinsider’s Pharmacy500 Careers Outlook report identifies key employment trends and workforce dynamics across Pharmacy500 companies. Check out this report to learn more about open position trends and the current state of the job market impacting the pharmacy supply chain!

Drug diversion software uses machine learning and rule-based algorithms to detect and prevent the theft, misuse, or redistribution of controlled substances. This report offers insight into Pharmacy500 companies in the drug diversion software category, including product comparisons, company insights, and more.

RXinsider’s Pharmacy500 Academy now offers training on controlled substance reporting, along with product comparisons and company breakdowns. Visit the Pharmacy500 Academy to learn more about controlled substance reporting in the pharmacy industry.

Pharmacy500

SOFTWARE

AdvanceNet Health Solutions
Agadia
American Pharmacy Cooperative, Inc. (APCI)
AnewHealth
Ark Business Services, Inc.
ARxIUM
Asembia
AssistRx
AssureCare LLC
athenahealth
Avel eCare
Aventi Health
Baxter
BD
Bluesight
Brightree by Resmed
C2 Keep
Capital Inventory, Inc
Care Services, LLC
CarepathRx
CarePoint
Cencora
Codonics
ConsortiEX Inc.
CoverMyMeds (McKesson Corporation)
CPS Solutions, LLC
CuraScriptSD
Cypress Software, Inc.
Datarithm
Digital Business Solutions, Inc.
DocStation
DoseMe
DosePacker, Inc.
DosePlanner
DrFirst
Drugstore2Door
DRX SOFTWARE LLC
Elsevier
Empirian Health
EnlivenHealth
Epic Systems Corporation
Epicor Software Corporation
Euclid Medical Products
EzriRx
EZSCRIPTRx
FFF Enterprises, Inc.
First Databank, Inc.
Fullscript
GeriMed, Inc.
HelioMetrics
ICU Medical
Imprivata
nfiniTrak, LLC
InfoWerks Data Services, LLC
Inmar Inc.
Innovaccer
Inovalon
InsightRX, Inc.
Institute for Safe Medication Practices (ISMP)
InStockRx
Intelliguard
International Medical Industries
Isak Computing (SiCompounding & SiPrescribe)
JFCRx
Keycentrix, LLC
Liberty Software
LifeFile
Loopback Health
Lumistry
MatchRX
McKesson Corporation
Medi-Dose, Inc./EPS, Inc.
Medicine-On-Time
Medigi
MEDITECH
MedMe Health
Merative
MIDAS Healthcare Solutions
Mobile MediClaim, Inc.
Noritsu Pharmacy Automation
Nuvai Medical Technologies
Omnicell
Optum
Oracle Health
OrderInsite, LLC
Outcomes
PCCA
PDR by ConnectiveRx
PeopleGrove
PEPID, LLC
phactMI
Pharmacolog USA, Inc.
PharmaForce
Pharmapod
PharmaPoint, LLC
PharmID, Inc.
Pillr Health
PK Telehealth (TCE Group)
Plenful
PointClickCare
PPOk
PreciseRX
Premier, Inc.
Prescryptive Health, Inc.
PrimeRx
Pyrls
QuicksortRx, Inc.
Quva
RedSail Technologies, LLC
Retail Management Solutions, LLC
Rx2Go
RxConnexion
RxPost
RxRise
RxScan
Sanford Guide
Scriptology
ScriptPro LLC
SoftWriters, Inc.
Speed Script
SpendMend
Sphinx Strategies
SPS Health
SRS Pharmacy Systems
STACK, LLC
STChealth
SuiteRx, LLC
SureCost, LLC
Surescripts
Swisslog Healthcare
TailorMed
Tecsys Inc.
Terso Solutions, Inc.
The Craneware Group
ThoroughCare, Inc.
TraceLink, Inc.
TrackTraceRx, Inc.
TransferMyRx
Trilogy MedWaste, Inc.
TruMed Systems, Inc.
UGO
United States Pharmacopeia (USP)
Vizient, Inc.
VPLRx
WeInfuse, LLC
Wind River Payments
Wolters Kluwer
Workflow Services
XiFin
Yardi Systems, Inc.
Yuyama USA, Inc.
Zebra Technologies Corp.

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