The 340B Drug Pricing Program is vital for safety-net healthcare providers, allowing them to enhance access to medications, reduce medication costs for vulnerable populations, and reinvest savings into community health initiatives. The 340B Drug Pricing Program is a U.S. federal program established under Section 340B of the Public Health Service Act of 1992. It requires pharmaceutical manufacturers that participate in the Medicaid Drug Rebate Program to provide outpatient drugs to eligible healthcare organizations, referred to as covered entities, at significantly reduced prices.